Nitroglycerin (glyceryl trinitrate) (GTN) has been an important part of the management of patients with angina or heart failure for over 135 years. Keywords: microcirculation, permeability, plethysmography Read more Caution is required when comparing data recorded at different sites even if corrected for the volume of soft tissue under study. We conclude that limb capillary filtration coefficient is dependent on the site of measurement. Isovolumetric venous pressure (the maximum pressure at which there is neither net filtration nor absorption at the microvascular wall) was similar in upper and lower limbs in both groups of subjects. In both studies capillary filtration coefficient was significantly higher when measured at the forearm than at the calf (group A: versus, p < 0.01 group B: versus, p < 0.01). In this study, forearm and calf capillary filtration coefficient were measured in healthy volunteers, either simultaneously (group A n = 11) or sequentially in random order (group B n = 11) using venous occlusion plethysmography, with the subject supine and the limb at heart level. Measurement is typically made by venous occlusion plethysmography using either the upper or lower limb, but a variety of measurement protocols have been used and the importance of the site of. Changes in capillary filtration coefficient have been described in a number of disease processes. The study confirms a pronounced antianginal effect produced by metoprolol (Metocard, Metocard-Retard) in patients with old myocardial infarction.Ĭapillary filtration coefficient is a critical determinant of fluid flux across the microvascular wall. The decrease of the relative time of synchronization in a part of the patients shows that in these patients, probably, pathological factors take place and their correction is impossible with the help of beta-blockers only. It reflects a recovery of the autonomic control and functional relations between the heart rhythm and peripheral circulation in ischemic heart disease patients with old myocardial infarction. Using of metoprolol raises the relative time of synchronization of the 0.1 Hz rhythms of cardiovascular system in ~35% of patients in the supine posture and in ~50% in the standing one. Reliable distinctions in the dynamic of the relative time of synchronization depending on the daily dose of Metocard were not revealed.Ĭonclusion. In the other patients the relative time of synchronization decreased by 19.96.7% in the supine posture and by 17.37.1 in the standing one. The increase of the relative time of 0.1 Hz-oscillations synchronization in the heart rhythm and in the vessels of microcirculation under three months of Metocard intake was revealed in 7 patients in the supine posture (by 13.4☘%) and in 10 patients in the standing posture (by 16.1☑0%). The number of intaken tablets of nitroglycerin was also reduced reliably (p<0,01). After three months of intake of maximal endurable doses of metoprolol the number of angina attacks was reduced in average from 243 to 107 (p<0,01) in the group. Clinical status of the patients before and after three months of metoprolol intake was assessed. A relative time of synchronization was defined. The phase of the compared 0.1 Hz rhythms was estimated. 0.1 Hz oscillations were singled out by the band-pass filtering of the signals of RR-chains and a pulsogram. Records were made before metoprolol administration and after 3 months of the regular drug intake.
DELTACAD 7.1 REGISTRATION
A simultaneous registration of RR-intervals of electrocardiogram and pulsogram from the distal phalanx of a forefinger was carried out in the probationers under tilt test during 10 minutes with the help of multichannel analyzer EEGA-21/26 «Entsefalan-131-03», model 3 produced by «Medicom-MTD», Russia. Maximal endurable doses of metoprolol (Metocard-Retard and Metocard, Polpharma) were administered to all the probationers. 20 patients with ischemic heart disease who had had myocardial infarction no less then 6 months ago aged 5912 were involved in the study. To study the dynamic of 0.1 Hz oscillations synchronization in the heart rhythm and in the vessels of microcirculation under metoprolol intake during three months in patients with old myocardial infarction. It is generally agreed that 0.1Hz oscillations characterize the basic properties of the autonomic control of functional components of cardiovascular system.Īim.
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